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Severe Se deficiency may impair the thyroids ability to produce or convert thyroid hormones, potentially exacerbating hypothyroidism symptoms, such as fatigue, weight gain, and cold intolerance [88]

2.3 Cases and control definition Cases were defined as individuals with a new (incident) diagnosis of SUD, including AUD, opioid use disorder (OUD), nicotine use disorder (NUD), or cocaine use disorder (CUD)

Part of that effect happens in the brain

Endogenous cysteine is generated primarily through the transsulfuration pathway, which converts methionine to cysteine 20